Antimicrobial-binding mesh increases healing with NPWT

Special mesh traps and inactivates bacteria and fungi could be used as alternative filler to gauze.

Researchers investigating an antimicrobial-binding mesh as filler during negative-pressure wound therapy have seen good results in a small animal trial, according to a new study published in ePlasty.

Wounds on the backs of eight pigs underwent 72 hours of NPWT using black foam, gauze or a pathogen-binding mesh. The study aimed to compare the materials for development of granulation tissue, and ingrowth of wound bed tissue in the wound filler.

Researchers found that the mesh, which is designed to bind to bacteria and fungi, produced more granulation tissue, leukocyte infiltration and tissue disorganisation in the wound bed than gauze, but less than foam. All three wound fillers caused microdeformation of the wound bed surface. However, little force was required to remove pathogen-binding mesh and gauze, while considerable force was needed to remove foam – because of the higher level of infiltration.

"This study shows that using pathogen-binding mesh as a wound filler for NPWT leads to a significant amount of granulation tissue in the wound bed, more than that with gauze, but eliminates the problems of ingrowth of the wound bed into the wound filler,” write the authors. “Pathogen-binding mesh is thus an interesting wound filler in NPWT."

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