This update provides an opportunity to explore contemporary advances in wound infection knowledge and practice. Since 2008, scientific and clinical understanding of chronic wound infection has developed significantly. In particular, awareness of the presence and impact of wound biofilm has advanced enormously; however, understanding of its pathogenesis is yet to be clarified fully. A holistic approach to individuals with, or at risk of, active wound infection remains essential to best practice in prevention, identification and management of wound infection. This is of particular importance in the context of increasing antibiotic resistance.